SAHVIR BHASKARUNI

Biomedical Engineering Student · Builder · Quantitative Biology Enthusiast

Profile picture of Sahvir Bhaskaruni

About Me

Hi! I'm Sahvir, a Biomedical Engineering student at the University of Virginia passionate about using quantitative and computational approaches to better understand biological systems. My work spans systems and synthetic biology, bioinformatics, and molecular modeling, in applications ranging from therapeutics to sustainable biotechnology.

I built this website to document and share my projects, research experiences, and ideas. Whether through mechanistic modeling, transcriptomics, or synthetic biology, I’m especially interested in how computational methods can be used to better understand, engineer, and predict complex biological behavior.

Research Interests

Quantitative Biology Systems Biology Synthetic Biology Multi-Scale Modeling

Links

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Current Work

Virginia iGEM 2025

Leading a synthetic biology project focused on enhancing biohydrogen production through engineered biological systems.

Lazzara Lab

Exploring RNA-deconvolution approaches to infer cell-cell signaling via bulk RNA-seq data.

Projects

Virginia iGEM 2025

Led a team developing a biological device-assisted methodology to enhance biohydrogen production via dark fermentation.

Synthetic Biology Metabolic Engineering Multi-Scale Modeling Bio-Energy iGEM
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Pan-Hantavirus CD4+ Epitope Identification for Broad-Spectrum Vaccine Design

Identifying CD4+ epitopes to evaluate the potential to develop a pan-hantavirus vaccine to elicit broad-spectrum immunity to hantavirus as a means of availing a public health threat.

Immunoinformatics Public Health Vaccinology
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Small Molecule PCDH1 Inhibitor Design

Identifying small molecule inhibitors of PCDH1 to serve as a competitive inhibitor of PCDH1-Andes orthohantavirus binding to contribute to developing a treatment.

Molecular Docking Drug Design Medicinal Chemistry
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Projects in Development

Writeup in Progress

Growth & Gene Essentiality in S. Pneumoniae

Evaluation of the relationship between growth conditions and gene essentiality in S. pneumoniae via metabolic modeling.

Analysis Complete

Logic-Based Modeling of TNF/NF-κB Signaling

The development and analysis of a simple logic-based model of TNF/NF-κB signaling to analyze infection-induced inflammation.

Analysis Complete

Agent-Based Modeling of Rhinovirus Infection in the Nasal Epithelium

Developing an agent-based model of rhinovirus infection in the nasal epithelium to analyze the impact of immunosuppression on infection dynamics.

Ongoing

Evaluating Heterogeneity in Microglial Cell-State Classifications

An exploration of the impact of clustering methods and parameters on the heterogeneity of microglial cell-state classifications across Alzheimer's and healthy microglial cell populations; and its biological implications for understanding microglial function.

Ongoing

SELEX Screening

The development of a computational pipeline to assist SELEX screening for aptamer design to identify immprove workflow efficiency and candidate selection.

Ongoing

Parameter Optimization

The development of a computational pipeline to assist in parameter optimization of large ODE/PDE mechanistic models using Bayesian sampling.

Ongoing

Bulk RNA-seq Deconvolution

Exploring bulk RNA-seq deconvolution approaches to infer cell-cell signaling.

Get in Touch

I enjoy meeting people who are excited about science and quantitative biology. Whether you want to discuss research, share ideas, or just connect, I'd love to hear from you.

sahvirb@gmail.com GitHub LinkedIn